The clearest window into your health and longevity is your mouth.
Breathing, sleep, the microbiome and chronic inflammation all meet in the mouth, yet most of medicine still treats it as a separate department. Oral Intelligence makes the case that it is one of the earliest and most readable signals of how the whole body is aging.
Your dental visit was built to answer one question.
Are there holes in the teeth. Everything else the mouth can tell you goes uncollected.
Not out of negligence, but because no one is asking for it. Training, reimbursement and the design of the appointment all point the same way. Meanwhile the literature on what the mouth reveals about the heart4,9, the brain5, metabolism13 and sleep2 has moved a long way past the chair.
That gap, between what the science establishes and what happens at a dental visit, is the subject of the book.
of US adults 30 and older have periodontitis. Among adults 65 and older, the figure is 59.8%.1
Eke et al., JADA 2018of an estimated 29.4 million American adults with obstructive sleep apnea are undiagnosed.2
Frost & Sullivan for the AASM, 2016bacterial species live in the mouth, a community with documented links to disease far from it.3
Dewhirst et al., J Bacteriol 2010Population estimates and observational associations, not individual risk estimates. See all evidence →
From the gumline to distant disease.
Four oral culprits, seven conditions, and the published evidence connecting them. Select any organism or condition to see what has been found, and how strong the evidence is.
Select an organism or a condition.
Each line is a published finding, labeled by the strength of its evidence. Association is not causation; the label tells you what kind of evidence stands behind each line.
Porphyromonas gingivalis
A principal periodontal pathogen. It produces gingipains, protein-cutting enzymes, and an enzyme (PPAD) that citrullinates human proteins.
- Cardiovascular diseaseAssociation
DNA of P. gingivalis detected inside human atheromatous plaque.4
- Alzheimer's diseaseAssociation + animal
Gingipains found in Alzheimer's brain tissue, tracking with tau; oral infection in mice reached the brain.5
- Pancreatic cancerProspective
Oral carriage associated with higher later risk of pancreatic cancer.8
- Rheumatoid arthritisMechanistic
Its PPAD enzyme citrullinates human proteins, the targets of rheumatoid autoantibodies.10
Fusobacterium nucleatum
A common oral anaerobe that bridges other species in dental plaque. Its FadA adhesin binds E-cadherin on human cells.
Aggregatibacter actinomycetemcomitans
Associated with aggressive forms of periodontitis. It produces leukotoxin A, which damages white blood cells.
Periodontitis: the dysbiotic gum community
Not a single organism: chronic inflammation driven by an imbalanced bacterial community below the gumline.
Cardiovascular disease
Atherosclerosis and blood-vessel function.
Alzheimer's disease
Progressive neurodegeneration with amyloid and tau pathology.
- P. gingivalisAssociation + animal
Gingipains found in Alzheimer's brain tissue, tracking with tau; oral infection in mice reached the brain.5
Colorectal cancer
Cancer of the colon and rectum.
Pancreatic cancer
Usually diagnosed late, when treatment options are limited.
Rheumatoid arthritis
Autoimmune joint disease marked by antibodies to citrullinated proteins.
Type 2 diabetes
Impaired glucose control and insulin resistance.
- PeriodontitisReview
A two-way relationship: each condition worsens the other.13
Adverse pregnancy outcomes
Including preterm birth and stillbirth.
- F. nucleatumCase report
One documented case traced an oral strain to a term stillbirth.12
From mechanism to action.
How you breathe, what lives in your saliva, what regeneration can and cannot do, and what to ask for at your next appointment.
The Inflection Point
The mouth is not an island. Why your dentist isn't asking, and the move from repair to regeneration.
The Breath
Nasal breathing, nitric oxide, the airway behind night-time grinding, and how a child's face is built.
The Oral Microbiome
An ecosystem, not an enemy. The organisms linked to distant disease, and how to rebuild rather than sterilize.
The Science of Peptides
Signaling molecules without the biohacking vocabulary, and an honest account of the evidence.
What Can Be Healed
Surgical recovery, gums, the jaw joint, bone and implants, nerves, and the airway appointment.
What to Ask For
ORIGIN, what treatment actually looks like, dentistry in the longevity era, and what to do Monday.
ORIGIN™ reads the mouth as one system.
Six domains, assessed in sequence, combined into a single picture of systemic risk. The book conceptualizes it; the practice runs it.
Select a domain.
ORIGIN assesses each domain in sequence, because each finding changes how the next is read. Tap a number on the wheel or a domain below.
Microbiome
Salivary analysis of the bacterial community and the specific pathogens with documented systemic associations.
TMJ & function
The jaw joints, the bite and how the system moves under load.
Neuromuscular
The muscles of the head and neck, pain patterns and the signals driving them.
Imaging
Structural views of joints, bone and airway that the eye cannot see in the chair.
Airway
Breathing pattern, airway anatomy and sleep-disordered breathing risk.
Biomarkers
Inflammatory and stress markers, including salivary cortisol, that place the oral findings in the context of the whole person.
Michael P. Gulizio
Two decades rebuilding mouths in New York City, a former NYU program director who trained dentists from around the world, and an equal number of years asking what the mouth reveals about the rest of the body.
Read the biography →“Oral Intelligence does not compete with Outlive or Protocols. It completes them.”On where the book sits
ORIGIN™
The precision oral-systemic assessment the book describes.
How it works → The practiceCore Smiles
An advanced practice in NoMad, Manhattan, covering the full scope of dentistry since 2007.
coresmiles.com →A bioactive oral care line
Developed with bioactive ingredients to support the oral microbiome rather than strip it. Launching in early 2027.
Name to be announcedBe the first to know.
Hear when Oral Intelligence is available, and receive early excerpts before launch. Nothing else.
Published by Keystone & Arch, New York.